“Homozygous familial hypercholesterolemia is a hereditary lipid disorder that leads to extremely premature cardiovascular events and mortality so it is critical to make the diagnosis as early as possible”

Christie M. Ballantyne, MD Professor of Medicine Chief, Sections of Cardiology and Cardiovascular Research Director, Center for Cardiometabolic Disease Prevention Baylor College of Medicine Houston, Texas

The natural history of HoFH is progressive

Patients with HoFH may experience myocardial infarction before the age of 10 years, particularly if they have the severe LDL receptor (LDLR)-deficient genotype

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Early and accurate diagnosis is critical

Given the progressive nature of the disease, early and accurate diagnosis is key to ensuring prompt disease management

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Learn more about early diagnosis >

Learn more about early diagnosis >

Consensus statements recommend lowering LDL-C to reduce the risk of cardiovascular morbidity and mortality

The extent of the reduction of cholesterol levels is a major determinant of survival in patients with HoFH

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